Description
Melanotan II research peptide
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). A lactam bridge between Asp and Lys gives it a stable ring structure and greater resistance to enzymatic breakdown than the native hormone. It acts as a non-selective agonist at the MC1, MC3, MC4 and MC5 melanocortin receptors and is studied in vitro in research on melanocortin receptor binding, selectivity and signalling.
Supplied as a lyophilised powder in a 10mg vial. Melanotan II is not a licensed medicine in the UK. We supply it strictly as a research reagent.
Specifications
| Name | Melanotan II (Melanotan 2, MT2) |
|---|---|
| Class | Melanocortin receptor agonist, cyclic heptapeptide, α-MSH analogue |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molecular formula | C50H69N15O9 |
| Molecular weight | ≈ 1024.2 g/mol |
| CAS number | 121062-08-6 |
| Form | White to off-white lyophilised powder in a sealed glass vial |
| Size | 10mg |
Where Melanotan II fits in research
Quality and testing
Read more about our process on the Quality & Testing page.
Storage and handling
Store the lyophilised powder at −20 °C, sealed and protected from light and moisture. Allow the vial to reach room temperature before opening to limit condensation. Prepare solutions according to your laboratory’s validated protocols, using appropriate PPE. Bacteriostatic water is available separately for laboratory use.
Frequently asked questions
What is Melanotan II?
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective agonist at several melanocortin receptors and is studied in vitro in research on melanocortin receptor binding and signalling.
Which receptors does Melanotan II act on?
Melanotan II is a non-selective melanocortin receptor agonist. It is active at MC1R, MC3R, MC4R and MC5R, which makes it a common reference compound when comparing receptor selectivity in laboratory models.
What is the difference between Melanotan II and PT-141?
PT-141 is a structural analogue of Melanotan II. The two share the same cyclic core, but Melanotan II ends in an amide (-NH2), while PT-141 ends in a free carboxylic acid (-OH). This small change is studied for its effect on receptor activity.
What is the Melanotan II sequence?
The sequence is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, a cyclic peptide formed by a lactam bridge between Asp and Lys. Its molecular formula is C50H69N15O9, with a molecular weight of about 1024.2 g/mol.
Is Melanotan II licensed in the UK?
No. Melanotan II is not a licensed medicine in the UK. We supply it strictly as a research reagent for in vitro laboratory work.
What purity is your Melanotan II?
Every batch is purity tested by Janoshik, an independent laboratory, using HPLC before it is released for sale.
How should Melanotan II be stored?
Store the lyophilised powder sealed at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Stability in solution should be validated within your own laboratory protocol.
Do you ship Melanotan II from the UK?
Yes. Orders placed before 3PM UK time, Monday to Friday, are normally dispatched the same day by Royal Mail Tracked 24. See our Shipping Policy.
Do you provide dosing or usage advice?
No. Melanotan II is supplied for in vitro laboratory research only. We do not provide dosage, administration or medical advice of any kind.
Research use only. This product is supplied strictly for in vitro laboratory research. It is not for human or animal use, and not for diagnostic or therapeutic purposes. By purchasing, you agree to our Research Use Disclaimer.
