Description
PT-141 research peptide
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and a melanocortin receptor agonist. It is a structural analogue of Melanotan II and acts mainly at the MC3 and MC4 receptors, which are expressed in the central nervous system. In the laboratory it is studied in research on melanocortin receptor binding, selectivity and signalling.
Supplied as a lyophilised powder in a 10mg vial. PT-141 is not a licensed medicine in the UK. We supply it strictly as a research reagent.
Specifications
| Name | PT-141 (bremelanotide) |
|---|---|
| Class | Melanocortin receptor agonist, cyclic heptapeptide |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular formula | C50H68N14O10 |
| Molecular weight | ≈ 1025.2 g/mol |
| CAS number | 189691-06-3 |
| Form | White to off-white lyophilised powder in a sealed glass vial |
| Size | 10mg |
Where PT-141 fits in research
Quality and testing
Read more about our process on the Quality & Testing page.
Storage and handling
Store the lyophilised powder at −20 °C, sealed and protected from light and moisture. Allow the vial to reach room temperature before opening to limit condensation. Prepare solutions according to your laboratory’s validated protocols, using appropriate PPE. Bacteriostatic water is available separately for laboratory use.
Frequently asked questions
What is PT-141?
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide that acts as an agonist at melanocortin receptors, mainly MC3R and MC4R. It is studied in vitro in research on melanocortin receptor binding and central signalling pathways.
Is PT-141 the same as bremelanotide?
Yes. Bremelanotide is the non-proprietary name for the peptide often referred to as PT-141 in research literature.
How is PT-141 related to Melanotan II?
PT-141 is a structural analogue of Melanotan II. The two share a cyclic melanocortin core, but PT-141 ends in a free carboxylic acid where Melanotan II has an amide. This small change is studied for its effect on receptor activity.
What is the PT-141 sequence?
The sequence is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, a cyclic peptide formed by a lactam bridge between Asp and Lys. Its molecular formula is C50H68N14O10, with a molecular weight of about 1025.2 g/mol.
What purity is your PT-141?
Every batch is purity tested by Janoshik, an independent laboratory, using HPLC before it is released for sale.
How should PT-141 be stored?
Store the lyophilised powder sealed at −20 °C, protected from light and moisture. Allow the vial to reach room temperature before opening. Stability in solution should be validated within your own laboratory protocol.
Do you ship PT-141 from the UK?
Yes. Orders placed before 3PM UK time, Monday to Friday, are normally dispatched the same day by Royal Mail Tracked 24. See our Shipping Policy.
Do you provide dosing or usage advice?
No. PT-141 is supplied for in vitro laboratory research only. We do not provide dosage, administration or medical advice of any kind.
Research use only. This product is supplied strictly for in vitro laboratory research. It is not for human or animal use, and not for diagnostic or therapeutic purposes. By purchasing, you agree to our Research Use Disclaimer.
